Partiendo de un análisis de la posición ambigua que tiene el arte en el mundo actual (entre la autonomía y la heteronomía), se formulan dos tesis. En primer lugar, se propone una tesis ontológica, según la cual el arte está constituido por un doble impulso: por un lado, un impulso constructivo, presente en toda praxis social y humana; por otro, un impulso destructivo, que actúa en los márgenes de la razón y de la sociedad y los sobrepasa. En segundo lugar, (...) se propone una tesis práctica, según la cual la adecuada tensión entre ambos impulsos es la condición de posibilidad de la libertad humana. Mediante una confrontación entre Hegel y Kafka, teniendo presentes ambas hipótesis, planteo un desplazamiento en la definición del ser humano como animal racional. Para finalizar, hago ver que se trata, en el fondo, de un debate sobre el destino del ser humano. (shrink)

cuad. 1. La filosofía antigua -- cuad. 2. La filosofía medieval -- cuad. 3. La filosofía moderna. pt. 1.

Die Schreibwerkstätten am Literaturhaus in Stuttgart haben in Deutschland Massstäbe gesetzt. Was vor über 10 Jahren als ein Angebot für Schülerinnen und Schüler begonnen hatte, mündete konsequenterweise auch in ein innovatives Programm zur Lehrerfortbildung: die Gesprächsreihe "Literatur und ihre Vermittler". Zehn Autorinnen und Autoren äusserten sich zu wesentlichen Fragen des literarischen Schreibens und gewährten einen sehr persönlichen Blick hinter die Kulissen. Wo und wann beginnt Literatur? Ist Schreiben erlernbar? Wann wird Sprache literarisch? Ist Scheitern die Voraussetzung für etwas Neues? Wer (...) bestimmt die Kriterien, was Qualität ist und was nicht? Diesen und anderen Fragen sind die Schriftsteller nachgegangen. Die Gesprächsreihe "Literatur und ihre Vermittler" wird gefördert von der Breuninger Stiftung Stuttgart. (shrink)

We develop the theory of symmetry for a two-level quantum system in oder to illustrate the main ideas of the general theory of symmetry in quantum theory. It is based on the diffeomorphism of the two-dimensional sphere S 2 onto the space of states ℂP 1 and the isomorphism between the groups Pℳ(2) and SO 3 (ℝ). In particular, rotational invariance leads to the appearance of the spin1/2 in a natural way.

The veins are cuticular structures that differentiate in precise patterns in insect wings. The genetic and molecular basis of vein pattern formation in Drosophila melanogaster is beginning to be unravelled with the identification and characterisation of the gene products that position the veins and direct their differentiation. Genes affecting the veins fall into two groups: transcriptional regulators that specify individual veins, and members of signalling pathways involved in patterning and differentiation of the veins. The elaboration of the vein pattern is (...) progressive in time and requires the coordinated activities of these signalling pathways and the transcription factors regulated by them. Although the network of genetic interactions that determine vein cell fate is well understood, very little is known about the cellular biology underlying the acquisition of vein histotype. BioEssays 25:443–451, 2003. © 2003 Wiley Periodicals, Inc. (shrink)

El concepto de segunda naturaleza promete proporcionar una explicación de cómo la naturaleza y la razón se pueden reconciliar. Pero dicho concepto está cargado de ambigüedad: se entiende como aquello que une todas las actividades cognitivas y se concibe como un tipo de naturaleza que puede ser modificada por actividades cognitivas. Se intenta investigar esta ambigüedad distinguiendo una concepción kantiana de otra hegeliana. Se sostiene que la idea de una transformación de un ser de prim- era naturaleza en un ser (...) de segunda naturaleza, que se encuentra en el corazón de la concepción kantiana, es errónea. (shrink)

Ariel es un ensayo publicado por el uruguayo José Enrique Rodó en 1900 y considerado como una de las obras de mayor influencia en el campo de la cultura y la política latinoamericanas. Es un texto breve compuesto de seis partes. Se caracteriza por su contenido filosófico y su tono pedagógico. Está dirigido principalmente a la juventud hispanoamericana, como señala el autor, para advertirles contra el utilitarismo y contra lo que él llama la nordomanía. Utiliza los personajes de La (...) tempestad de William Shakespeare: Próspero, Ariel y Calibán. (shrink)

Airway mucin secretion is important pathophysiologically and as a model of polarized epithelial regulated exocytosis. We find the trafficking protein, SNAP23, selectively expressed in secretory cells compared with ciliated and basal cells of airway epithelium by immunohistochemistry and FACS, suggesting that SNAP23 functions in regulated but not constitutive epithelial secretion. Heterozygous SNAP23 deletant mutant mice show spontaneous accumulation of intracellular mucin, indicating a defect in baseline secretion. However mucins are released from perfused tracheas of mutant and wild-type mice at the (...) same rate, suggesting that increased intracellular stores balance reduced release efficiency to yield a fully compensated baseline steady state. In contrast, acute stimulated release of intracellular mucin from mutant mice is impaired whether measured by a static imaging assay 5 min after exposure to the secretagogue ATP or by kinetic analysis of mucins released from perfused tracheas during the first 10 min of ATP exposure. Together, these data indicate that increased intracellular stores cannot fully compensate for the defect in release efficiency during intense stimulation. The lungs of mutant mice develop normally and clear bacteria and instilled polystyrene beads comparable to WT mice, consistent with these functions depending on baseline secretion that is fully compensated. (shrink)

Este artigo busca apresentar as fenomenologias de Husserl e de Heidegger não como dois caminhos isolados na construção do que ulteriormente representou a tradição fenomenológica, mas, ao contrário, identificando pontos de intersecção entre estes dois autores. Para isso recorre ao texto Mein Weg in die Phänomenologie, de Heidegger, publicado em 1963, no qual o já septuagenário filósofo recorre ao seu itinerário pessoal junto à fenomenologia e ao quanto a obra e, posteriormente, a figura de Husserl se mostrariam marcantes na elaboração (...) de seu pensamento – desde suas iniciais intuições como estudante de teologia, passando pelos primeiros anos como professor universitário e culminando na publicação de Sein und Zeit. O reconhecimento deste itinerário exige, porquanto, que a obra de Heidegger seja enxergada em sua relação com a fenomenologia husserliana, donde não apenas recebera o método necessário para a instauração de uma ontologia fundamental, mas a radicalidade inerente à própria atividade filosofante, isto é, o direcionamento às coisas mesmas e, por ele, à essência do pensamento, à coisa do pensar. (shrink)

Pretendemos neste trabalho sustentar a ideia de que, seguindo um percurso que vai de Sein und Zeit aos textos mais tardios, a compreensão do pensar, especialmente tendo em conta a íntima relação desta compreensão com o conceito de existência, esteve caracterizada pela concepção de finitude. Assim, segundo esta hipótese, o pensamento da história do ser teria como meta revelar ao mesmo tempo o retraimento do ser que se opera por um pensar – chamemo-lo de “expropriador” – e a necessidade de (...) se inaugurar um novo pensar, que é o que estaria em jogo na viragem. Intuídos já em Sein und Zeit morte e finitude, firmar-se-iam como conceitos nucleares para a compreensão da importância, do alcance e da posteridade da filosofia heideggeriana. (shrink)

The COVID-19 pandemic has subjected most of the world’s population to unprecedented situations, like national lockdowns, health hazards, social isolation and economic harm. Such a scenario calls for urgent measures not only to palliate it but also, to better cope with it. According to existential positive psychology, well-being does not simply represent a lack of stress and negative emotions but highlights their importance by incorporating an adaptive relationship with them. Thus, suffering can be mitigated by, among other factors, adopting an (...) attitude of positive reframing, maintaining hope, existential courage, life appreciation, engagement in meaningful activities, and prosociality. The conglomerate of these elements has been recently denominated as meaning-centered coping. In this study, we evaluated the protective role of this type of coping on mental health. A sample of 12,243 participants from 30 countries across all continents completed measures of Meaning-Centered Coping Scale, depression, stress, anxiety and stressful COVID-19 related conditions they experienced. Results indicated that meaning-centered coping was strongly associated with diminished symptoms of stress, anxiety, and depression. Moreover, it moderated various relationships between vulnerability factors and markers of psychological distress, especially in the case of depression. These findings call for attention to meaning-centered coping approaches in the context of hardship, such as the current COVID-19 health crisis. In these difficult times, decision-makers and health organizations may integrate these approaches into their guidelines. (shrink)

Internet-based health research is increasing, and often offers financial incentives but fraudulent behavior by participants can result. Specifically, eligible or ineligible individuals may enter the study multiple times and receive undeserved financial compensation. We review past experiences and approaches to this problem and propose several new strategies. Researchers can detect and prevent Internet research fraud in four broad ways: through the questionnaire/instrument ; through participants' non-questionnaire data and seeking external validation through computer information,, and 4) through study design. These approaches (...) each have pros and cons, and raise ethical, legal, and logistical questions, given that ethical tensions can emerge between preserving the integrity of research vs. protecting the privacy and confidentiality of study respondents. While past discussions concerning the ethics of online research have tended to focus on the participants' ability to trust the researchers, needs now arise to examine researchers' abilities to trust the participants. This analysis has several critical implications for future practice, policy, and research. (shrink)

This study aimed to explore the role of two models of well-being in the prediction of psychological distress during the COVID-19 pandemic, namely PERMA and mature happiness. According to PERMA, well-being is mainly composed of five elements: positive emotions, engagement, relationships, meaning in life, and achievement. Instead, mature happiness is understood as a positive mental state characterized by inner harmony, calmness, acceptance, contentment, and satisfaction with life. Rooted in existential positive psychology, this harmony-based happiness represents the result of living in (...) balance between positive and negative aspects of one's life. We hypothesized that mature happiness would be a more prominent protective factor during the present pandemic than the PERMA composite. A total of 12,203 participants from 30 countries responded to an online survey including the Depression Anxiety Stress Scale (DASS-21), the PERMA-Profiler, and the Mature Happiness Scale-Revised (MHS-R). Confirmatory factor analyses indicated that PERMA and mature happiness were highly correlated, but nonetheless, they represented two separate factors. After controlling for demographic factors and country-level variables, both PERMA Well-being and MHS-R were negative predictors of psychological distress. Mature happiness was a better predictor of stress, anxiety, and general distress, while PERMA showed a higher prediction of depression. Mature happiness moderated the relation between the perceived noxious effects of the pandemic and all markers of distress (depression, anxiety, stress, and total DASS-21). Instead, PERMA acted as a moderator in the case of depression and stress. These findings indicate that inner harmony, according to the mature happiness theory, is an essential facet of well-being to be taken into consideration. The results of this study can also orient policies aimed to alleviate the negative effects of the pandemic on mental health through the promotion of well-being. (shrink)

The quantization of the magnetic flux in superconducting rings is studied in the frame of a topological model of electromagnetism that gives a topological formulation of electric charge quantization. It turns out that the model also embodies a topological mechanism for the quantization of the magnetic flux with the same relation between the fundamental units of magnetic charge and flux as there is between the Dirac monopole and the fluxoid.